Production and Characterization of a β-Cyclodextrin Inclusion Complex with Platonia insignis Seed Extract as a Proposal for a Gastroprotective System
نویسندگان
چکیده
Platonia insignis Mart, Clusiaceae, known as bacuri, is a species native to Brazil that, in studies with extract of the seed its fruit, showed antioxidant activity against free radicals. Products such properties may be great importance treatment peptic ulcers since this pathology associated inflammatory process caused by action Cyclodextrins are molecules capable forming inclusion complexes other molecules, affecting their physicochemical and improving pharmacokinetic characteristics. Thus, work aimed produce, characterize, evaluate gastroprotective effect complex β-cyclodextrin (β-CD) bacuri seeds hexanic (BSHE). In characterization complex, an apparent stability constant (Kc) 416 mol/L was obtained solubility study; BSHE:β-CD m/m (g) complexation ratios at 1:9, 2:8, 3:7 were 5.51%, 21.46%, 20.11%, respectively. The formation observed FTIR technique, indicating disappearance bands characteristic BSHE (2960 cm−1 1755 cm−1) when compared spectra pure or physical mixture β-CD, X-ray diffraction, which indicated loss crystallinity, typical signals presentation intense amorphization, BSHE, incorporated β-CD pockets. evaluation activity, through absolute ethanol-induced gastric lesions mice, both reduced lesions, 100 mg/kg dose having greatest effect. also able reduce from ischemia reperfusion, 50 being most effective. BSHE:β-CD, dose, MDA levels mucosa, possible it concluded that between possible, formulation enhanced protective activity.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2022
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app13010058